Clinical features and prognostic factors associated with adrenocortical carcinoma: Lahey Clinic Medical Center experience
Adrenocortical carcinoma is a rare tumor associated with a commonly poor prognosis. However, data on the natural history and response to therapy of patients with this malignancy have often been conflicting. Our objective of this retrospective study was to evaluate the clinical course and survival
Adrenocortical Carcinoma: A Single Institution Experience
Adrenocortical carcinoma (ADCC) ranks among the least common malignant endocrine tumors. Surgical resection is considered the most important treatment for this neoplasm. Medical records of patients with the diagnosis of ADCC between 1990 and 2000 were reviewed. Patient and pathologic factors were
Adrenocortical Carcinoma
Adrenocortical carcinoma Definition Adrenocortical carcinoma is a malignant growth that originates in the cortex, or the outer portion, of one of the two adrenal glands. Description There are two adrenal glands in the body. Each one is paired with a kidney. The adrenal gland rests atop the kidney,
Adrenocortical Carcinoma Arising From a Long-standing Adrenal Mass
Adrenocortical carcinoma is a rare tumor with a dismal prognosis. In stark contrast, benign incidental adrenal lesions are detected commonly on routine abdominal imaging. We report a case of a 74-year-old man with a history of germ cell testicular carcinoma who presented with a 4.8-cm left adrenal
A case of myxoid adrenocortical carcinoma with extensive lipomatous metaplasia
* We report a combination of unusual myxoid change and extensive lipomatous metaplasia of an adrenocortical carcinoma. The patient was a 38-year-old man with hypertension and heart failure. Radiographic examination revealed the presence of a left adrenal tumor, and adrenalectomy was performed. The
Myxoid adrenal cortical carcinoma - A rare variant of adrenocortical carcinoma
Dear Sir, Adrenocortical carcinomas are malignant neoplasms of the adrenal cortex generally affecting patients in their fourth and fifth decades of life. Myxoid change is a very rare phenomenon in adrenocortical carcinoma, and only 11 similar cases have been reported to date. Myxoid changes in
Coincident choroid plexus carcinoma and adrenocortical carinoma with elevated p53 expression: A case report of an 18-month-old boy with no family history of cancer
A Case Report of an 18-Month-Old Boy With No Family History of Cancer * We describe a young patient with no known family history of cancer who presented at 18 months with 2 advanced primary tumors, choroid plexus carcinoma and adrenal cortical carcinoma. Immunohistochemical studies demonstrated
PET/CT vs CT in Adrenocortical Carcinoma
In an article e-published on December 20 ahead of print in the Journal of Clinical Endocrinology and Metabolism, Leboulleux et al. from the Institut Gustave Roussy (Villejuif, France) reported on a study comparing PET/CT and CT in diagnosis and prognosis of adrenocortical carcinoma. The study
Pathologic quiz case: A 57-year old man with hypertension and hypokalemia: Pathologic diagnosis: Aldosterone-producing adrenocortical adenoma with concurrent low-grade renal cell carcinoma, clear cell type
A 57-year-old man with a past medical history significant for hypertension and non-insulin-dependent diabetes mellitus presented for evaluation of chronic hypokalemia. Initially, the low potassium levels were attributed to his antihypertensive medication. However, hypokalemia persisted despite
Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression: a case report of an 18-month-old boy with no family history of cancer. .
The p53 tumor suppressor gene is the most commonly mutated gene in human cancers. The p53 gene regulates cell proliferation and DNA repair by inhibiting the cell cycle at G1/S, so that loss of function may lead to aberrant cell kinetics and tumor growth. (1) Germline mutations in the p53 gene
