Current Approach to Diagnosis and Management of Chronic Lymphocytic Leukemia
The care of patients with chronic lymphocytic leukemia (CLL) has changed dramatically during the past decade. This review summarizes the work-up of lymphocytosis and the current diagnostic criteria and management of CLL. Although clinical staging (Rai and Binet) remains the foundation for
Quantification of ZAP70 mRNA in B Cells by Real-Time PCR Is a Powerful Prognostic Factor in Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is heterogeneous with respect to prognosis and clinical outcome. The mutational status of the immunoglobulin variable heavy chain region (IGHV) has been used to classify patients into 2 groups in terms of overall survival (OS) and clinical
Chronic Lymphocytic Leukemia: Diagnosis and Treatment
Traditional, the goal of therapy in chronic lrymphocytlc leukemia (CLL) has been palliative, with first-line therapy using alkylating agent and/oc involved field radiotherapy (depending on the stage of disease and sites of Involvement) became of the older age of affected patients and the low rate
Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma
* Objective: To assess the clinical relevance of chemokine receptor expression on the progression of B-cell chronic lymphocytic leukemia (B-CLL). * Patients and Methods: Peripheral blood mononuclear cells from 45 patients with B-CLL were purified and compared with lymph node samples collected from
Spontaneous remission of B-cell chronic lymphocytic leukemia associated with T lymphocytic hyperplasia in bone marrow. .
ABSTRACT: Spontaneous remissions in B-cell chronic lymphocytic leukemia (B-CLL) are rare and none of them has been studied with immunophenotyping (by flow cytometry and immunohistochemistry) and genotyping. In this patient, studied after spontaneous remission had occurred, there was a residual
Ionizing radiation and chronic lymphocytic leukemia.
The U.S. government recently implemented rules for awarding compensation to individuals with cancer who were exposed to ionizing radiation while working in the nuclear weapons complex. Under these rules, chronic lymphocytic leukemia (CLL) is considered to be a nonradiogenic form of cancer. In other
Detection of Richter's Transformation of Chronic Lymphocytic Leukemia by PET/CT
Our objective was to evaluate the accuracy of PET/CT for the diagnosis of Richter's transformation of chronic lymphocytic leukemia (CLL) to diffuse large cell lymphoma. Methods: A retrospective study was performed of 37 patients with CLL who underwent ^sup 18^F-FDG PET/CT at our institution between
Infection and immunity in chronic lymphocytic leukemia
Patients having chronic lymphocytic leukemia (CLL) are at increased risk for infectious morbidity and mortality. The predisposition to infections in CLL patients has many components, including both immunodeficiency related to the leukemia itself (humoral and cellular immune dysfunction) and the
Modification of immunocytochemical ZAP-70 assay for potential clinical application in B-cell chronic lymphocytic leukemia
Abstract: The ZAP-70 protein is a member of the Syk/ZAP protein tyrosine kinase family, normally expressed in T cells and NK cells but not found in normal, mature B cells. The protein plays a critical role in the initiation of T-cell signaling. Leukemic cells from patients with B-cell chronic
Hodgkin's disease in an elderly patient with B-Cell chronic lymphocytic leukemia
Introduction Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder characterized by an increased number of morphologically mature appearing but immunologically incompetent lymphocytes in the peripheral blood, bone marrow, spleen, and lymph nodes. It is an indolent disease,
