Malignant Melanoma: an update. .
Cutaneous melanoma is a tumor derived from activated or genetically altered epidermal melanocytes, the result of complex interactions between genetic, constitutional, and environmental factors. (1-7) Melanoma is the most rapidly increasing malignancy in the white population, and it has a high
Malignant Melanoma in the 21st Century, Part 1: Epidemiology, Risk Factors, Screening, Prevention, and Diagnosis
Malignant melanoma is an aggressive, therapy-resistant malignancy of melanocytes. The incidence of melanoma has been steadily increasing worldwide, resulting in an increasing public health problem. Exposure to solar UV radiation, fair skin, dysplastic nevi syndrome, and a family history of melanoma
Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape
Malignant melanoma presents a substantial clinical challenge. Current diagnostic methods are limited In their ability to diagnose early disease and accurately predict Individual risk of disease progression and outcome. The lack of adequate approaches to properly define disease subgroups precludes
Understanding Signaling Cascades in Melanoma[dagger]
ABSTRACT Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control, metabolism, motility and the
Malignant melanoma: An update
* Context.-The rapidly developing fields of melanoma research are revolutionizing the current concepts on melanoma etiology and pathogenesis and are introducing newer diagnostic techniques and potential therapeutic approaches. Objectives.-To present the most current concepts on the etiology and
Malignant Melanoma in the 21st Century, Part 2: Staging, Prognosis, and Treatment
Critical to the clinical management of a patient with malignant melanoma is an understanding of Its natural history. As with most malignant disorders, prognosis Is highly dependent on the clinical stage (extent of tumor burden) at the time of diagnosis. The patient's clinical stage at diagnosis
Melanoma: treatment guidelines for patients .
With publication of the Melanoma: Treatment Guidelines for Patients, patients have their first access to information about the way melanoma is treated at the nation's leading cancer centers. Originally developed for cancer specialists by the National Comprehensive Cancer Network (NCCN), these
Role of Nuclear Medicine in the Management of Cutaneous Malignant Melanoma*
Malignant melanoma of the skin is one of the most lethal cancers. The disease may spread either locally or regionally and to distant sites through predictable or unpredictable metastatic pathways. Accurate staging and restaging of disease are required for appropriate treatment decision making.
Radioguided sentinel lymph node biopsy in malignant cutaneous melanoma
Radioguided Sentinel Lymph Node Biopsy in Malignant Cutaneous Melanoma* The procedure of sentinel lymph node biopsy in patients with malignant cutaneous melanoma has evolved from the notion that the tumor drains in a logical way through the lymphatic system, from the first to subsequent levels. As
Metastatic Malignant Melanoma of the Gastrointestinal Tract
Malignant melanoma is one of the most common malignancies to metastasize to the gastrointestinal (GI) tract. Metastases to the GI tract can present at the time of primary diagnosis or decades later as the first sign of recurrence. Symptoms may include abdominal pain, dysphagia, small bowel
